Pharmacist's alert as common statins mistake can bring 'unwanted side effects'

A pharmacist has warned that millions of people on long-term medications may be undermining their effectiveness simply by consuming them at incorrect times during the day. Peter Thnoia, superintendent pharmacist at NHS-approved online pharmacy PillTime, explains that managing multiple prescriptions can be bewildering, but the timing of each tablet remains equally crucial as remembering to consume it.

He has cautioned that failing to read instructions thoroughly can render medicines less potent and heighten the risk of adverse side effects.

"Too often, people don't read or fully follow the instructions that come with their medication – and that can have a real impact on how well those medicines work," said Peter, who has more than 20 years' experience in the pharmaceutical sector.

"Something as simple as taking a pill at the wrong time of day, or not alongside food when it's needed, can reduce its effectiveness or even cause unwanted side effects. Building a consistent routine and understanding the 'when' as well as the 'what' of your medication is key to getting the best results for your health."

Among the most frequently prescribed medications consumed at inappropriate times are particular statins, cholesterol-reducing drugs that help safeguard against heart disease. Millions of Britons, especially those beyond 40, receive prescriptions for statins such as simvastatin and lovastatin.

These particular statins are most effective during evening hours since the body's cholesterol manufacturing reaches its peak overnight. Nevertheless, numerous individuals consume them during morning hours purely through routine, alongside their other medicines.

"Many people take their statins in the morning, simply because it's when they take the rest of their medication," Peter explained.

"But for certain types, such as simvastatin, research shows they work best when taken in the evening – when the body naturally produces more cholesterol. If you take them at the wrong time, you could be reducing their effectiveness without even realising it."

It isn't solely prescribed drugs that can be influenced by timing – nutritional supplements are frequently consumed at inappropriate times, diminishing their advantages. Iron tablets, for instance, are commonly consumed during morning hours alongside breakfast or a swift cup of tea before dashing out of the house.

However, food – especially dairy products – and beverages such as tea or coffee can substantially decrease the amount of iron the body takes in.

"There are plenty of people who take morning supplements like iron tablets to 'get them through the day' – often gulped down quickly before heading to work," Peter said.

"But iron is actually absorbed best on an empty stomach, and things like dairy, tea or coffee can block absorption. That's why the best advice is to take iron tablets as soon as you get up, before breakfast."

Peter's advice emphasises the significance of planning – especially for individuals juggling multiple prescriptions. Leighton Humphreys, CEO of PillTime, suggests that the company's pouching service can be a crucial aid, eliminating the stress and uncertainty of managing medicines: "I know it's not the most exciting task, especially if you have multiple medications that need to be taken at different times of the day or night. But the only way to get the most from your medication is to carefully follow the instructions from your pharmacist.

If you can't do that, whether due to lack of time or physical ability, there are options to have your medications pre-sorted into pouches. This means the pharmacist will review the instructions for each prescription and organise your medicines into clearly labelled pouches showing the dose, date and time. There's no guesswork – just the right medication at the right time."

Statins, like Simvastatin

Best consumed in the evening as cholesterol production peaks at night. A dose before bed can enhance effectiveness.

Iron supplements

Best on an empty stomach, ideally first thing in the morning before breakfast. Bear in mind, dairy, tea, and coffee can hinder absorption.

Levothyroxine, for an underactive thyroid

Best to take first thing in the morning, at least 30 minutes prior to consuming food and drink to minimise absorption.

Some pain relief, such as Ibuprofen and Naproxen

Known as NSAIDS, these tablets can upset the stomach – so it's recommended to take them with food or a glass of milk.

Certain ADHD medications, such as methylphenidate

Stimulant ADHD medications can lead to insomnia if taken too late in the day, hence morning doses are advised to manage symptoms during waking hours without disturbing sleep.