The parasite's hidden secret: It infiltrates the body, shutting down the nerves that sense pain

Schistosoma mansoni, a parasitic worm transmitted through water, has become adept at sneaking into the human body. Its larvae penetrate the skin, but neither pain nor itching are felt during the process. The result is a chronic disease affecting millions: schistosomiasis.

SUPPRESSES THE FEELING OF PAIN Scientists have now solved the secret behind this insidiousness. According to the research, the parasite secretes molecules that suppress certain nerve cells in the host’s skin. These nerves are known as TRPV1+ neurons, and they normally alert the brain to danger with stimuli such as heat, burning or itch. It also tries to prevent invasion by triggering an immune response. PAINKILLER HOPE Immunologist De’Broski Herbert from Tulane School of Medicine in the US says that this discovery could pave the way for a new generation of painkillers. Herbert said, “If we can identify molecules that block the activation of nerve cells, we can develop an alternative to current opioid-based treatments.” TESTED ON MICE The researchers conducted experiments by infecting mice and comparing them with control groups. It was observed that the immune response in the nerve cells of those infected was significantly reduced. This proved that the parasite suppresses nerves, making it easier for it to enter the body. Scientists believe these molecules could be used for two different purposes: developing preventative treatments against schistosomiasis for people exposed to contaminated water and paving the way for new drugs to alleviate chronic nerve pain. However, they emphasize that further research is needed due to their immunosuppressive effects.