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Against bronchiolitis, the effectiveness of Beyfortus in preventing serious infections confirmed

Against bronchiolitis, the effectiveness of Beyfortus in preventing serious infections confirmed

By The New Obs with AFP

Published on , updated on

Beyfortus, a treatment designed to immunize infants against the main virus that causes bronchiolitis, was developed by Sanofi in partnership with the British company AstraZeneca.

Beyfortus, a treatment designed to immunize infants against the main virus that causes bronchiolitis, was developed by Sanofi in partnership with the British company AstraZeneca. FRED TANNEAU/AFP

Beyfortus, a treatment designed to immunize babies against the main virus that causes bronchiolitis, is highly effective in preventing serious respiratory syncytial virus (RSV) infections in infants, confirms a large analysis published this Friday, May 2.

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National studies had already concluded that this treatment had limited hospitalizations of babies, but the one revealed in "The Lancet Child & Adolescent Health" provides the most solid overview to date of the state of knowledge.

Although it is generally not serious, bronchiolitis, which causes breathing difficulties, particularly in babies during the first 6 months of their life, can sometimes lead to trips to the emergency room and hospitalization.

Beyfortus is part of a series of innovative treatments aimed at preventing or limiting infection by the main virus that causes this disease. Nirsevimab, the name of the molecule, is not a vaccine, even though it is injectable, but a preventative treatment that prevents the virus from infecting the body.

An 83% reduction in the risk of hospitalization

Following successful clinical trials, this monoclonal antibody – developed by Sanofi in partnership with the British company AstraZeneca – was approved by several regulatory agencies in 2023 and subsequently made available in certain high-income countries.

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According to the meta-analysis published this Friday, of twenty-seven studies conducted during the 2023-2024 RSV season in five countries (France, Italy, Luxembourg, Spain, United States), nirsevimab reduces the risk of hospitalization due to infection by the main bronchiolitis virus by 83% on average, admissions to intensive care by 81% and cases of lower respiratory tract infections by 75% in children 12 months and younger.

This immunization appeared to be more effective in preventing hospitalization of infants over 3 months old (81%) than those 3 months old or younger (76%), its authors observed.

Differences in effectiveness between countries

The effectiveness of nirsevimab in reducing hospitalizations related to bronchiolitis, however, appeared to vary depending on the country, being higher in the United States (93%) than in Spain (83%) and France (76%).

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A possible explanation, according to the researchers, is a higher proportion of infants at high risk of serious infection who received this treatment in the United States, where this category was prioritized during the 2023-2024 bronchiolitis season due to limited supplies of Beyfortus. Further research would be needed to verify this hypothesis.

This meta-analysis has limitations, its authors acknowledge. The studies included were observational, which may lead to biases related to underlying health problems, socioeconomic status, or regional differences in access to care.

By The New Obs with AFP

Le Nouvel Observateur

Le Nouvel Observateur

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